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- Matt Pack, RB, AC Flora – rushed for 226 yards and 4 TDs and passed for 1 TD in win over Union County
- Willis Lane, RB, Camden – rushed for 204 yards in win over Lugoff-Elgin
- Hunter Helms, QB, Gray – passed for more than 400 yards and 6 TDs in win over Swansea
- Jy Tolen, QB, Gilbert – passed for more than 300 yards in win over Batesburg-Leesville
- Roger Pedroni, QB Chapin: Was 23-of-30 for 271 yards in the air and also ran for 82 yards with four total TDs in win over Mid-Carolina.
- Aveon Smith, QB, White Knoll had 321 yards of offense and five TDs in win over Colleton County.
- Jafari Pearson, QB, Camden – 156 yards passing with 3 TDs
- Leroy Isaac, LB, Westwood – had a fumble recovery for a TD and two sacks in win over Blythewood
- Ty Olenchuk, QB, Dutch Fork – threw for 212 yards and a TD in win over Spring Valley
- Marvin Gantt, RB, Batesburg-Leesville – rushed for 144 yards and two TDs in loss to Gilbert.
- Tre Robinson, QB, Batesburg-Leesville – threw for 212 yards and 3 TDs in loss to Gilbert
- Braden Walker, RB, River Bluff – rushed for 84 yards and three TDs in win over RNE
- Jackson Stone, QB, River Bluff – rushed for two TDs.
- Elijah Ogden, QB,Lexington – rushed for two TDs and passed for 1 TD in win over Dreher
- Taylor Mathias, RB, Lexington – rushed for 159 yards and 1 TD
- Aveon Smith, QB, White Knoll – passed for 264 yds, 4 TDs and rushed for 57 yds and 1 TD
- Terrell Coleman, RB, AC Flora – rushed for 132 yds and 1 TD in win over Union County
- Jackson Muschamp, QB, Hammond – passed for 297 yds and 3 TDs in win over Ben Lippen
- Andre Wilson, WR, Hammond – 190 yds receiving and 2 TDs
- OD Dollison, WR, Gray – 194 yards receiving, 3 Tds and one kick return for a TD
- Jake Cowen, QB, Cardinal Newman – passed for 92 yds and 2 TDs in win over Porter Gaud
- Noah Bell, QB , Saluda – passed for 223 yards and 6 TDs in win over Ridge Spring-Monetta
- Nicolas Gilliam, RB, Westwood – rushed for 119 yards and 1 TD
- Josh Strickland, QB, Blythewood – passed for 148 yds and 1 TD in loss to Westwood
- Anthony Lyles, WR, Camden – 5 receptions, 101 yards and 3 TDs
