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- Hayden Vasquez, QB, Sumter – 14 of 24 for 110 yds, 1 rushing TD in win over Blythewood
- Josh Strickland, QB, Blythewood – 15 of 25 131 yds, 1 TD
- Jy Tolen, QB, Gilbert – 217 yards passing and 65 yards rushing, 2 TDs in win over Strom Thurmond
- Tyrell Coleman, RB, AC Flora – rushed for 165 yds and 1 TD in win over OW
- Tyler Robinson, RB, AC Flora – rushed for 115 yds and 1 TD
- Mikah Davis, RB, Camden – rushed for 156 yds in win over Chester
- Willis Lane, RB, Camden – rushed for 146 yds and 2 TDs
- Jackson Stone, QB, River Bluff – 164 yds passing and 3 TDs in win over Chapin
- Riley Myers, RB, River Bluff – 105 yds rushing and 2 TDs
- Roger Pedroni, QB, Chapin – passed for 332 yds, 2TDs in loss
- Deontay Baker, RB, Brookland-Cayce – rushed for 3 TDs in win over Midland Valley
- Peyton Whitten, QB, Brookland-Cayce – passed for 2 TDs
- Derrick Belton, RB, CA Johnson – rushed for 151 yds, 3 TDs in win over Eau Claire
- Leroy McKenzie, RB, CA Johnson – rushed for 108 yds and 2 TDs
- KZ Adams, RB, Gray – rushed for 150 yds and 5 TDs in win over Calhoun County
- DJ Jackson, LB/DE, Sumter – 14 tackles, 6.5 for losss, 1 FF, and 2.5 sacks in win over Blythewood
- Justus Boone, DE, Sumter – 8 tackles, 1.5 for loss, 1.5 sack
- Donovan Johnson, RB, White Knoll – 107 yds rushing in loss to Spring Valley
- Anthony Wilson, QB, Spring Valley – 12 of 25 for 157 yds and 3 TDs, and rushed for 82 yds and 1 TD in win over White Knoll
- Lawrence Scott, QB,Byrnes – 197 yds and 3 TDs in loss to Dorman
- Rahjai Harris, RB, Byrnes – 167 yds and 1 TD